The trajectory of gray matter development in Broca's area is abnormal in people who stutter.
Identifieur interne : 000D25 ( Main/Exploration ); précédent : 000D24; suivant : 000D26The trajectory of gray matter development in Broca's area is abnormal in people who stutter.
Auteurs : Deryk S. Beal [Canada] ; Jason P. Lerch [Canada] ; Brodie Cameron [Canada] ; Rhaeling Henderson [Canada] ; Vincent L. Gracco [Canada] ; Luc F. De Nil [Canada]Source :
- Frontiers in human neuroscience [ 1662-5161 ] ; 2015.
Abstract
The acquisition and mastery of speech-motor control requires years of practice spanning the course of development. People who stutter often perform poorly on speech-motor tasks thereby calling into question their ability to establish the stable neural motor programs required for masterful speech-motor control. There is evidence to support the assertion that these neural motor programs are represented in the posterior part of Broca's area, specifically the left pars opercularis. Consequently, various theories of stuttering causation posit that the disorder is related to a breakdown in the formation of the neural motor programs for speech early in development and that this breakdown is maintained throughout life. To date, no study has examined the potential neurodevelopmental signatures of the disorder across pediatric and adult populations. The current study aimed to fill this gap in our knowledge. We hypothesized that the developmental trajectory of cortical thickness in people who stutter would differ across the lifespan in the left pars opercularis relative to a group of control participants. We collected structural magnetic resonance images from 116 males (55 people who stutter) ranging in age from 6 to 48 years old. Differences in cortical thickness across ages and between patients and controls were investigated in 30 brain regions previously implicated in speech-motor control. An interaction between age and group was found for the left pars opercularis only. In people who stutter, the pars opercularis did not demonstrate the typical maturational pattern of gradual gray matter thinning with age across the lifespan that we observed in control participants. In contrast, the developmental trajectory of gray matter thickness in other regions of interest within the neural network for speech-motor control was similar for both groups. Our findings indicate that the developmental trajectory of gray matter in left pars opercularis is abnormal in people who stutter.
DOI: 10.3389/fnhum.2015.00089
PubMed: 25784869
PubMed Central: PMC4347452
Affiliations:
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Beal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Communication Sciences and Disorders and the Institute for Stuttering Treatment and Research, Faculty of Rehabilitation Medicine, University of Alberta Edmonton, AB, Canada ; Neuroscience and Mental Health Institute, University of Alberta Edmonton, AB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Communication Sciences and Disorders and the Institute for Stuttering Treatment and Research, Faculty of Rehabilitation Medicine, University of Alberta Edmonton, AB, Canada ; Neuroscience and Mental Health Institute, University of Alberta Edmonton, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="Lerch, Jason P" sort="Lerch, Jason P" uniqKey="Lerch J" first="Jason P" last="Lerch">Jason P. Lerch</name><affiliation wicri:level="1"><nlm:affiliation>Program in Neuroscience and Mental Health, The Hospital for Sick Children Toronto, ON, Canada ; Department of Medical Biophysics, University of Toronto Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Program in Neuroscience and Mental Health, The Hospital for Sick Children Toronto, ON, Canada ; Department of Medical Biophysics, University of Toronto Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Cameron, Brodie" sort="Cameron, Brodie" uniqKey="Cameron B" first="Brodie" last="Cameron">Brodie Cameron</name><affiliation wicri:level="1"><nlm:affiliation>Department of Communication Sciences and Disorders and the Institute for Stuttering Treatment and Research, Faculty of Rehabilitation Medicine, University of Alberta Edmonton, AB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Communication Sciences and Disorders and the Institute for Stuttering Treatment and Research, Faculty of Rehabilitation Medicine, University of Alberta Edmonton, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="Henderson, Rhaeling" sort="Henderson, Rhaeling" uniqKey="Henderson R" first="Rhaeling" last="Henderson">Rhaeling Henderson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Communication Sciences and Disorders and the Institute for Stuttering Treatment and Research, Faculty of Rehabilitation Medicine, University of Alberta Edmonton, AB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Communication Sciences and Disorders and the Institute for Stuttering Treatment and Research, Faculty of Rehabilitation Medicine, University of Alberta Edmonton, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="Gracco, Vincent L" sort="Gracco, Vincent L" uniqKey="Gracco V" first="Vincent L" last="Gracco">Vincent L. Gracco</name><affiliation wicri:level="1"><nlm:affiliation>Haskins Laboratories New Haven, CT, USA ; Centre for Research on Brain, Language and Music, McGill University Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Haskins Laboratories New Haven, CT, USA ; Centre for Research on Brain, Language and Music, McGill University Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="De Nil, Luc F" sort="De Nil, Luc F" uniqKey="De Nil L" first="Luc F" last="De Nil">Luc F. De Nil</name><affiliation wicri:level="1"><nlm:affiliation>Department of Speech-Language Pathology, University of Toronto Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Speech-Language Pathology, University of Toronto Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author></analytic><series><title level="j">Frontiers in human neuroscience</title><idno type="ISSN">1662-5161</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The acquisition and mastery of speech-motor control requires years of practice spanning the course of development. People who stutter often perform poorly on speech-motor tasks thereby calling into question their ability to establish the stable neural motor programs required for masterful speech-motor control. There is evidence to support the assertion that these neural motor programs are represented in the posterior part of Broca's area, specifically the left pars opercularis. Consequently, various theories of stuttering causation posit that the disorder is related to a breakdown in the formation of the neural motor programs for speech early in development and that this breakdown is maintained throughout life. To date, no study has examined the potential neurodevelopmental signatures of the disorder across pediatric and adult populations. The current study aimed to fill this gap in our knowledge. We hypothesized that the developmental trajectory of cortical thickness in people who stutter would differ across the lifespan in the left pars opercularis relative to a group of control participants. We collected structural magnetic resonance images from 116 males (55 people who stutter) ranging in age from 6 to 48 years old. Differences in cortical thickness across ages and between patients and controls were investigated in 30 brain regions previously implicated in speech-motor control. An interaction between age and group was found for the left pars opercularis only. In people who stutter, the pars opercularis did not demonstrate the typical maturational pattern of gradual gray matter thinning with age across the lifespan that we observed in control participants. In contrast, the developmental trajectory of gray matter thickness in other regions of interest within the neural network for speech-motor control was similar for both groups. Our findings indicate that the developmental trajectory of gray matter in left pars opercularis is abnormal in people who stutter. </div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">25784869</PMID><DateCompleted><Year>2015</Year><Month>03</Month><Day>18</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>01</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1662-5161</ISSN><JournalIssue CitedMedium="Print"><Volume>9</Volume><PubDate><Year>2015</Year></PubDate></JournalIssue><Title>Frontiers in human neuroscience</Title><ISOAbbreviation>Front Hum Neurosci</ISOAbbreviation></Journal><ArticleTitle>The trajectory of gray matter development in Broca's area is abnormal in people who stutter.</ArticleTitle><Pagination><MedlinePgn>89</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fnhum.2015.00089</ELocationID><Abstract><AbstractText>The acquisition and mastery of speech-motor control requires years of practice spanning the course of development. People who stutter often perform poorly on speech-motor tasks thereby calling into question their ability to establish the stable neural motor programs required for masterful speech-motor control. There is evidence to support the assertion that these neural motor programs are represented in the posterior part of Broca's area, specifically the left pars opercularis. Consequently, various theories of stuttering causation posit that the disorder is related to a breakdown in the formation of the neural motor programs for speech early in development and that this breakdown is maintained throughout life. To date, no study has examined the potential neurodevelopmental signatures of the disorder across pediatric and adult populations. The current study aimed to fill this gap in our knowledge. We hypothesized that the developmental trajectory of cortical thickness in people who stutter would differ across the lifespan in the left pars opercularis relative to a group of control participants. We collected structural magnetic resonance images from 116 males (55 people who stutter) ranging in age from 6 to 48 years old. Differences in cortical thickness across ages and between patients and controls were investigated in 30 brain regions previously implicated in speech-motor control. An interaction between age and group was found for the left pars opercularis only. In people who stutter, the pars opercularis did not demonstrate the typical maturational pattern of gradual gray matter thinning with age across the lifespan that we observed in control participants. In contrast, the developmental trajectory of gray matter thickness in other regions of interest within the neural network for speech-motor control was similar for both groups. Our findings indicate that the developmental trajectory of gray matter in left pars opercularis is abnormal in people who stutter. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Beal</LastName><ForeName>Deryk S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Department of Communication Sciences and Disorders and the Institute for Stuttering Treatment and Research, Faculty of Rehabilitation Medicine, University of Alberta Edmonton, AB, Canada ; Neuroscience and Mental Health Institute, University of Alberta Edmonton, AB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lerch</LastName><ForeName>Jason P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Program in Neuroscience and Mental Health, The Hospital for Sick Children Toronto, ON, Canada ; Department of Medical Biophysics, University of Toronto Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cameron</LastName><ForeName>Brodie</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Communication Sciences and Disorders and the Institute for Stuttering Treatment and Research, Faculty of Rehabilitation Medicine, University of Alberta Edmonton, AB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Henderson</LastName><ForeName>Rhaeling</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Communication Sciences and Disorders and the Institute for Stuttering Treatment and Research, Faculty of Rehabilitation Medicine, University of Alberta Edmonton, AB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gracco</LastName><ForeName>Vincent L</ForeName><Initials>VL</Initials><AffiliationInfo><Affiliation>Haskins Laboratories New Haven, CT, USA ; Centre for Research on Brain, Language and Music, McGill University Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Nil</LastName><ForeName>Luc F</ForeName><Initials>LF</Initials><AffiliationInfo><Affiliation>Department of Speech-Language Pathology, University of Toronto Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 DC007603</GrantID><Acronym>DC</Acronym><Agency>NIDCD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 DC012502</GrantID><Acronym>DC</Acronym><Agency>NIDCD NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>03</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Front Hum Neurosci</MedlineTA><NlmUniqueID>101477954</NlmUniqueID><ISSNLinking>1662-5161</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Broca’s area</Keyword><Keyword MajorTopicYN="N">cortical thickness</Keyword><Keyword MajorTopicYN="N">developmental disorders</Keyword><Keyword MajorTopicYN="N">developmental stuttering</Keyword><Keyword MajorTopicYN="N">inferior frontal gyrus</Keyword><Keyword MajorTopicYN="N">motor control</Keyword><Keyword MajorTopicYN="N">neurodevelopment</Keyword><Keyword MajorTopicYN="N">speech production</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>08</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>02</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>3</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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Beal</name></noRegion><name sortKey="Cameron, Brodie" sort="Cameron, Brodie" uniqKey="Cameron B" first="Brodie" last="Cameron">Brodie Cameron</name><name sortKey="De Nil, Luc F" sort="De Nil, Luc F" uniqKey="De Nil L" first="Luc F" last="De Nil">Luc F. De Nil</name><name sortKey="Gracco, Vincent L" sort="Gracco, Vincent L" uniqKey="Gracco V" first="Vincent L" last="Gracco">Vincent L. Gracco</name><name sortKey="Henderson, Rhaeling" sort="Henderson, Rhaeling" uniqKey="Henderson R" first="Rhaeling" last="Henderson">Rhaeling Henderson</name><name sortKey="Lerch, Jason P" sort="Lerch, Jason P" uniqKey="Lerch J" first="Jason P" last="Lerch">Jason P. Lerch</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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